My clinical interests are primarily in inpatient care; particularly of
newborns and infants with critical congenital heart disease. My research
interests are in the short and long term sequelae of neonatal and infant
heart surgery. I am currently the principal investigator of a multi-center,
international trial involving the prophylactic use of milrinone lactate in
the prevention of low cardiac output after cardiac surgery (PRIMACORP?
trial). At CHOP, I was also a study physician in the randomized,
placebo-controlled trial investigating the use of Allopurinol in the
prevention of death, seizures and cardiac arrest following neonatal surgery.
While at Boston Children's Hospital, I was a study physician in the Second
Natural History Study (NHS-2) sponsored by the NIH. I conducted the pilot
study and was the principal study physician for the "Boston Circulatory
Arrest Trial" (randomization of low flow bypass vs. circulatory arrest
during the arterial switch operation) from 1987-1992. In addition, I
prospectively followed and published extensively about a group of nearly 600
patients following the arterial switch operation. Finally, I was also the
senior author and PI of a cross sectional study of the survivors of the
first 500 Fontan operations performed at Boston Children's.
My interests in the short and long term outcomes of complex CHD has
continued at Children's Hospital of Philadelphia, with prospective and
retrospective studies underway for HLHS, the Ross procedure for aortic valve
disease, and infant repair of tetralogy of Fallot.
In the American Heart Association, I am the past chair of the
Communications Committee and a former at-large member of the Executive
Committee of the Council on Cardiovascular Disease in the Young. I am also a
member of the Pediatric Cardiology Committee of the American College of
Cardiology, and on the Organizing Committee and Board of Directors of the
Pediatric Cardiac Intensive Care Society.
Bellinger DC, Wypij D, Kuban KCK, Rappaport LA,
Hickey PR, Wernovsky G, Jonas RA, Newburger JW.
Developmental and neurologic status of children at four years of age
after heart surgery with hypothermic circulatory arrest or low-flow
cardiopulmonary bypass. Circulation 100:526-532;
Marino BS, Wernovsky G, Rychik J, Bockoven JR, Godinez
RI, Spray TL.
Early results of the Ross procedure in simple and complex left
heart disease. Circulation 100 (suppl II);
Mahle WT, Clancy RR, Moss E, Gerdes M, Jobes DR, Wernovsky G.
Neurodevelopmental outcome and lifestyle assessment in school-age
and adolescent children with hypoplastic left heart syndrome.
Cohen MI, Bush D, Ferry RJ, Jr., Spray TL, Moshang T, Jr.,
Wernovsky G, Vetter VL. Somatic growth in children with single
ventricle. Cardiol Young 10:447-457; 2000
Wernovsky G, Stiles KM, Gauvreau K, Gentles TL, duPlessis AJ,
Bellinger DC, Walsh AZ, Burnett J, Jonas RA, Mayer JE Jr, Newburger
Cognitive development after the Fontan operation.
Gaynor JW, Wernovsky G, Rychik J, Rome JJ, DeCampli WM, Spray TL.
Outcome following single-stage repair of coarctation with
ventricular septal defect. Eur J Cardiothorac Surg
Mott AR, Spray TL, Gaynor JW, Godinez RI, Nicolson SC, Steven JM,
DeCampli WJ, Schears GJ, Wernovsky G. Improved early results with
cavopulmonary connections for functional single ventricle.
Cardiol Young 2001;11:3-11.
Wernovsky G, Rubenstein SD eds. Cardiovascular Disease in the
Neonate. Clinics in Perinatology. Philadelphia: W.B.